Title: An Isometry-invariant Spectral Approach for Macro-molecular Docking.
Abstract:
'The Protein Docking Problem' is the generic phrase which refers to
finding the sections/sites or segments of protein molecules on which
other protein molecules may dock (or bind). These docking sites are
very essential in the discovery of new drugs (during Drug Design) for
treating several diseases. Unfortunately, the current methods for
finding such docking sites are cumbersome and computationally
expensive. Meaning only big research labs with expensive dedicated
computing machines have the means of exploring proteins for such
medical analysis. Our research therefore seeks to drastically simplify
this explorative process by focusing on computations applied to the
spectral representation of the complex 3-dimensional protein objects,
thereby enabling smaller research labs, professors and students alike
with regular computers to achieve similar analytical capabilities.